No. 6 Houston vs. Cincinnati
When: Thursday, Sept. 15, 7:30 p.m. ET (ESPN)
The Line: Houston (-8)
Head coach Tom Herman said both Greg Ward Jr. and Duke Catalon will play after sitting out against Lamar. The Bearcats are thinking upset after a road win over Pyrdue, but Houston is to complete of a team to let that happen.
Prediction: Houston (-8)
No. 25 Miami vs. Appalachian State
When: Saturday, Sept. 17, noon ET (ESPN)
The Line: Miami (-3.5)
It’s possible—perhaps even likely—the Hurricanes start slowly because of the environment. However, Kaaya presents a much larger downfield passing threat than Joshua Dobbs, who rarely tested a formidable yet susceptible secondary. App State has a great defensive team, but in the end they don’t have enough offense to pull this out.
Prediction: Miami (-3.5)
No. 2 Florida State vs. No. 10 Louisville
When: Saturday, Sept. 17, noon ET (ABC)
The Line: Florida State (-2.5)
The Seminoles will be without starting safety Derwin James for the contest, and that’s no small void. However, FSU has outstanding depth in the secondary, a terrific defensive line and a week to prepare for Jackson’s dazzling talent. Louisville QB Lamar Jackson has been amazing the first two weeks. Florida State is just to talented of a team to lose this game.
Prediction: Florida State (-2.5)
No. 1 Alabama vs. No. 19 Ole Miss
When: Saturday, Sept. 17, 3:30 p.m. ET (CBS)
The Line: Alabama (-10)
OLE Miss has won this matchup the last two years, this year Alabama bounces back in a major way. Quarterback Jalen Hurts leads Saban’s squad to an early lead, and the defense pounces on Kelly like Florida State did during the second half to earn a comfortable win.
Prediction: Alabama (-10)
No. 22 Oregon vs. Nebraska
When: Saturday, Sept. 17, 3:30 p.m. ET (ABC)
The Line: Nebraska (-3)
One critical factor of this game is which team generates the most takeaways—and it might just be one. Heading into the contest, the teams have a combined three turnovers.
Prediction: Oregon (+3)
No. 3 Ohio State vs. No. 14 Oklahoma
When: Saturday, Sept. 17, 7:30 p.m. ET (FOX)
The Line: Ohio State (-1.5)
Oklahoma needs to redeem itself after a loss to Houston. Ohio State wants to prove a young roster is ready for prime time. Saturday’s contest has College Football Playoff implications.
Prediction: Oklahoma (+1.5)
Mississippi State vs. No. 20 LSU
When: Saturday, Sept. 17, 7 p.m. ET (ESPN2)
The Line: LSU (-12)
The college football world has a proper suspicion that Danny Etling will replace Brandon Harris under center. Plus, Leonard Fournette is expected to return after sitting out one game. But head coach Les Miles has confirmed neither topic. The main thing here is either way the Tigers are just flat out more talented than the Bulldogs.
Prediction: LSU (-12)
USC vs. No. 7 Stanford
When: Saturday, Sept. 17, 8 p.m. ET (ABC)
The Line: Stanford (-9)
USC’s thin defensive line is not exactly a recipe for success opposite Christian McCaffrey and the bruising Stanford offense. Alabama amassed 242 yards and three touchdowns in the opener. This should be over quick.
Prediction: Stanford (-9)
No. 12 Michigan State vs. No. 18 Notre Dame
When: Saturday, Sept. 17, 7:30 p.m. ET (NBC)
The Line: Notre Dame (-7.5)
The Irish must deal with a rested Michigan State squad looking to erase a sluggish season opener from memory. Additionally, the Spartans present arguably the toughest defense quarterback DeShone Kizer and Co. will encounter in 2016.
Prediction: Notre Dame (-7.5)
Week one against the spread (6-3)
Week Two against the spread (5-4)