NORMAN, OK - SEPTEMBER 17: J.T. Barrett #16 of the Ohio State Buckeyes walks with his offense off the field in the second half of their game against the Oklahoma Sooners at Gaylord Family Oklahoma Memorial Stadium on September 17, 2016 in Norman, Oklahoma. (Photo by Scott Halleran/Getty Images)

Duke vs. No. 7 Louisville

WhenFriday, 7 p.m. ET (ESPN)

The Line: Louisville (-35.5)

Duke beat Notre Dame on the road and then lost to Virginia at home the next week. Consistency is not the Blue Devils’ friend. The Cardinals are coming off a bye week after a tough loss at Clemson. Lamar Jackson will go off in this game.

Pick: Louisville (-35.5)


No. 20 West Virginia vs. Texas Tech

WhenSaturday, noon ET (Fox Sports 1)

The Line: West Virginia (-1)

Patrick Mahomes II guides a Red Raiders attack that ranks No. 2 nationally with 55.2 points per game. However, the defense has allowed 44 points or more three times. It is the Big 12 so expect a basketball score, I like the Red Raiders at home.

Pick: Texas Teck (+1)


No. 1 Alabama vs. No. 9 Tennessee

When: Saturday, 3:30 p.m. ET (CBS)

The Line: Alabama (-13)

In the last 21 games, the Crimson Tide are 20-0 when forcing one turnover and 0-1 when finishing with zero. Tennessee has yet to play a mistake-free game in that regard this season. The Volunteers cannot afford to get behind double digits to the Tide if they do they will now win.. I think the Tide wins, but 13 points is a lot to give a team like Tennessee.

Pick: Tennessee (+13)


North Carolina State vs. No. 3 Clemson

WhenSaturday, noon ET (ABC)

The Line: Clemson (-17.5)

Clemson finally is clicking on offense and will be way too much for the Wolfpack to handle.

Pick: Clemson (-17.5)


No. 10 Nebraska vs. Indiana

When: Saturday, 3:30 p.m. ET (ABC/ESPN2)

The Line: Nebraska (-4)

The Hoosiers are playing well, upsetting Michigan State and playing tough at Ohio State last week. The Cornhuskers have not really proven if they are a top 10 yet. This will be a tough game for the Cornhuskers, but I do think they will pull it out.

Pick: Nebraska (-4)


No. 24 Western Michigan vs. Akron

WhenSaturday, 3:30 p.m. ET (CBS Sports Network)

The Line: Western Michigan (-10.5)

Led by potential All-American receiver Corey Davis, Western is 6-0 overall and 5-1 against the spread in 2016. Plus, the program is 7-2 ATS on the road since the beginning of 2015. The Broncos are one of the best teams in the country and will run over Akron.

Pick: Western Michigan (-10.5)


North Carolina vs. No. 16 Miami

When: Saturday, 3:30 p.m. ET (ABC/ESPN2)

The Line: Miami (-6.5)

Can these two teams recover from last week’s big losses? According to Matt Porter of the Palm Beach Post, several key ‘Canes—including quarterback Brad Kaaya, top receiver Stacy Coley, and linebacker Shaq Quarterman—are banged up. Plus, safety Jamal Carter will miss the first half while serving a targeting penalty.

Pick: North Carolina Tar Heels (+6.5)


No. 12 Ole Miss vs. No. 22 Arkansas

When: Saturday, 7 p.m. ET (ESPN)

The Line: Ole Miss (-7.5)

Arkansas has struggled to defend each of the spread-based attacks from three Football Bowl Subdivision opponents. Chad Kelly and the Rebels should reach 40 points.

Pick: Ole Miss (-7.5)


No. 2 Ohio State vs. No. 8 Wisconsin

WhenSaturday, 8 p.m. ET (ABC)

The Line: Ohio State (-10.5)

Wisconsin has major offensive issues, but they have an excellent defense. In the End, the Badgers will have to score points and I just don’t think they can score enough of them.

Pick: Ohio State (-10.5)


Last week against the spread: 8-2

For the year against the spread: 39-21